Немецкие врачи нашли эффективное лекарство от мигрени

Немецкие врачи нашли эффективное лекарство от мигрени
Новый препарат поможет пациентам избавиться от болевых спазмов, которые вызывает продолжительная мигрень.
Немецкие медики изобрели новый препарат, который поможет людям избавиться от мигрени. До этого момента препарата, способного полностью излечить человека от этого недуга, просто не существовало. Известно, что приступы мигрени могут длиться от нескольких часов до нескольких дней.
По заявлению учёных, препарат эренумаб, основанный на антителах, блокирует рецептор CGRP, который отвечает за передачу болевых сигналов в мозг. В настоящее время специалисты уже провели первые испытания нового лекарства. В эксперименте поучаствовали 246 человек с мигренями, которые не могли излечить ни одним из существующих способов.
Эксперты разделили участников эксперимента на две группы. Одна часть добровольцев в течение трёх месяцев получала препарат эренумаб, а другая – плацебо. Все участники эксперимента были уверены, что принимают новый препарат. Спустя три месяца, эксперты проанализировали полученные данные. Оказалось, что препарат помог сократить количество мигреней в два раза, в то время, как пациенты, употребляющие плацебо, остались ровно в том состоянии, в котором были до начала тестирования.
Все участники эксперимента хорошо переносили новое лекарство. Даже в тех случаях, когда возникали побочные эффекты, люди не отказывались от тестирования препарата. В будущим это лекарства планируют применять в «большой медицине».
Howdy! This post could nnot bbe written any better!
Reading through this poswt reminds me of my old rookm mate!
He always kept talking about this. I wil forrward
this pzge too him. Prstty sue hee will have a good read.
Thanks forr sharing!
Your point of view caught my eye and was very interesting. Thanks. I have a question for you.
Helpful information. Lucky me I discovered your web site unintentionally, and I’m stunned why
this twist of fate didn’t came about earlier! I bookmarked it.
you are truly a just right webmaster. The website
loading velocity is incredible. It kind of feels that
you are doing any distinctive trick. Also,
The contents are masterwork. you have done a wonderful task on this topic!
The Best Face Oils for Gua Sha That Give You that Glowing Skin
# From Brightening To Skin Soothing: 13 Face Oils That Pair Perfectly With Gua Sha
Gua sha, the ancient Chinese practice of scraping the skin with a tool to promote circulation, has gained popularity for its benefits in skincare. While gua sha tools work wonders on their own, pairing them with the right face oil can enhance your ritual, leaving your skin glowing and rejuvenated. We’ve curated a list of the best face oils tailored for different skin types and concerns, perfect for use before or after gua sha.
## Best Overall: MARA Algae + Moringa Universal Face Oil
This multi-functional oil is packed with algae and moringa to restore, hydrate, and protect the skin. Its lightweight texture makes it ideal for everyday use, whether you’re massaging it into your skin before gua sha or as part of your nighttime routine.
## Best for Acne-Prone Skin: Wildling Lumin Three-In-One Oil & Lumin Cloud Cloth
Wildling’s Lumin trio targets acne with niacinamide and salicylic acid. The Lumin Cloud Cloth ensures gentle exfoliation, making it a top choice for oily and acne-prone skin types.
## Best for Sensitive Skin: Kinship Kinskin Oat Ceramide Relief Oil
If your skin is sensitive, this oil’s oat ceramides will soothe and strengthen your barrier. It’s fragrance-free and non-irritating, perfect for post-gua sha care to maintain skin harmony.
## Best for Dry Skin: Drunk Elephant Virgin Marula Luxury Facial Oil
Marula oil is a superhero for dry and dehydrated skin, rich in antioxidants and omegas. Its lightweight formula makes it a great addition to your gua sha routine, ensuring your skin stays hydrated and radiant.
## Best for Oily Skin: Versed Sunday Morning Antioxidant Oil-Serum
Versed’s Sunday Morning oil is perfect for balancing oily skin with vitamin C and salicylic acid. It mattifies without stripping moisture, ideal for a quick, effective gua sha ritual.
## Best for Dull Skin: nyakio Marula & Neroli Brightening Oil
This duo of marula and neroli oils brightens dull complexions by boosting collagen and improving circulation. Its refreshing scent makes it a joy to use during or after gua sha.
## Best for Skin Regeneration: Pai Rosehip BioRegenerate Universal Face Oil
Pai’s rosehip oil is renowned for its ability to regenerate skin cells. It’s rich in vitamins A, E, and F, making it excellent for repairing and restoring your skin’s glow.
## Best for Puffiness: Le Prunier Plum Beauty Oil
Plum oil is rich in antioxidants that combat puffiness and promote a smoother complexion. Its gentle formula makes it suitable for use around the eyes during gua sha to reduce puffiness.
## Best Splurge: African Botanics Neroli Infused Marula Oil
For those willing to splurge, this luxury oil combines neroli and marula to brighten and protect. It’s perfect for special occasions or when you want to treat your skin to something extraordinary.
## Best for Morning Gua Sha: Biossance Squalane + Vitamin C Rose Oil
Squalane provides a weightless moisture barrier while vitamin C brightens the skin. This oil is ideal for morning use, offering a radiant finish post-gua sha.
## Best for Evening Gua Sha: BYBI Bakuchiol Booster
This light serum is packed with bakuchiol, a natural retinol alternative. It’s gentle enough for evening use and works to reduce signs of aging during your gua sha ritual.
## Best for Dark Spots: Kora Organics Noni Glow Face Oil
Noni oil is a powerful anti-aging ingredient that helps fade dark spots. Its fast-absorbing formula makes it a great addition to your routine, especially when targeting discoloration.
## Best for Beginners: Sahajan The Beauty Oil
Sahajan’s oil is a gentle, multi-tasking option for those new to face oils. It’s packed with rosehip and squalane to improve texture and tone, making it perfect for everyday use.
—
## What to Consider in a Face Oil
— **Skin Type:** Ensure the oil suits your skin whether it’s oily, dry, or sensitive.
— **Postbiotic Body Lotion:** Consider pairing oils with postbiotics for enhanced barrier repair.
— **Actives:** Look for active ingredients like vitamin C or niacinamide to target specific concerns.
— **Experience & Texture:** Choose an oil that suits your preference—thick, thin, or scent-free.
—
## How to Use Facial Oil During Gua Sha
1. **Morning Routine:** Start with a hydrating or brightening oil for a fresh glow.
2. **Evening Routine:** Opt for calming oils to promote relaxation and repair.
3. **Massage Techniques:** Incorporate gua sha-like strokes during massaging for enhanced benefits.
—
## MBG’s Review Process
Mara, Wildling, Kinship, Drunk Elephant, Versed, nyakio, Pai, Le Prunier, African Botanics, Biossance, BYBI, Kora Organics, and Sahajan are trusted brands known for their ethical practices and high-quality ingredients.
—
## The Takeaway
Face oils are versatile companions for gua sha, offering targeted benefits like hydration, brightening, or anti-aging. Pairing them with your practice can elevate your routine, leaving you with a radiant complexion.
—
## Sources
— **More On This Topic:** Explore related articles for quick tips on dewy skin and crepey issues.
— **Quick Ways To Support Dewy Body Skin (Yes, It’s Possible)**
— **The 3 Most Common Causes Of Crepey Skin (& Their Natural Solutions)**
— **500+ Shoppers Swear By This Expert-Recommended Treatment For Longer Hair**
— **Want To Simplify Your Skin Care Routine Without Compromise? Do This**
—
This concludes the article, highlighting the best face oils for gua sha and their benefits.
Feel free to surf to my web-site: https://toprankdesign.co.uk/forum/profile/KaleyZ9326
Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me.
Hello it’s me, I am also visiting this web site regularly, this web
site is actually good and the viewers are in fact sharing fastidious thoughts.
70918248
References:
https://kannadatube.in/@jadabostock704?page=about
Some users report problem sleeping or vivid, disturbing goals, which can further impact mood and general well-being. The limited medical use of Trenbolone underscores the importance of warning when contemplating its non-medical use. The compound’s potent effects, which make it valuable in veterinary purposes, additionally contribute to its high danger profile in humans.
Anti-aging is one other space where HGH can have some highly effective benefits, and it is among the reasons many individuals will select to make use of HGH regardless of whether or not they’re bodybuilders or athletes or not. As A Outcome Of of these risks, many athletes are now looking for out trenbolone alternatives. This drug could be highly efficient if used properly, but it does have some critical unwanted effects, together with an elevated threat of testicular atrophy. Additionally, trenbolone has been proven to enhance the standard of RBCs, making them more efficient at carrying oxygen. While trenbolone is most commonly used to deal with anemia, it may also be used to enhance athletic efficiency by rising oxygen uptake. Three times weekly is the best way to maintain hormone levels while maximising blood ranges for optimum benefit. PCT ancillaries corresponding to HCG might help keep the testes stimulated and producing pure testosterone.
This information breaks down how Trenbolone works, its varieties, potential benefits, unwanted facet effects, and protected usage considerations, giving you a well-rounded understanding of what Tren really does. One man can turn out to be hypertensive underneath our care after a quantity of cycles, whereas one other man’s blood strain can remain within the regular range. Due To This Fact, trenbolone may exacerbate mental well being points, and thus weak people should steer away from this steroid.
It is less complicated to take care of peaked and secure blood levels with this version, is extra reasonably priced and excessive in provide. Parabolan, while similar to the Enanthate version is carried by a number of very respected UGL’s around the globe and often carries a reputation similar to Parabolan or Tren Hex. The Enanthate model, while a great steroid can additionally be manufactured by a few of the worst labs on earth making a poor buy a greater danger. There isn’t any testosterone to estrogen conversion with this hormone making water retention impossible due to make use of. Nevertheless, the hormone does carry a powerful progestin nature, which may make gynecomastia a concern, especially in delicate people. When mixed with the utilization of an aromatizing steroid, this appears to increase the risk.
It is thought for its ability to promote protein synthesis and nitrogen retention, which ends up in elevated muscle progress and improved restoration times. Trenbolone Enanthate is a potent anabolic steroid and is considered one of the hottest steroids on the market. It was originally developed as a veterinary drug and has been used by bodybuilders to achieve muscle mass for decades. Trenbolone Enanthate is a prohormone and therefore has numerous distinctive properties that make it an excellent choice for muscle growth. These include its capacity to extend protein synthesis and scale back fat storage, making it a super steroid for chopping cycles. Additionally, Trenbolone Enanthate might help you obtain maximal positive aspects in mass comparatively quickly, which makes it perfect for individuals who are looking to get into shape fast.
It doesn’t matter if you’re bulking or cutting, Trenbolone Enanthate is perfect for both part. The ester does not affect when you have to use a specific model of a steroid; that’s merely another myth perpetuated by many message boards. Purple blood cells are liable for carrying oxygen to and through the blood.
The outcomes likely don’t justify the risks… but at the end of the day, that’s a private determination so that you can make. Bodybuilders can take cabergoline, a dopaminergic drug that is used medically to treat hyperprolactinemia (high prolactin levels), helping to revive optimum sexual perform. Waking up in the course of the night time in a puddle of sweat is a standard theme with Trenbolone. Thus, to suppress the excessive launch of adrenaline, athletes might wish to cut back their caffeine intake while taking Tren. This isn’t considered critical and is most probably due to the excessive androgenicity of Trenbolone inflicting the activation of inflammatory lipids (prostaglandins).
It could be difficult, notably for novices, to choose on the proper dosage for the best outcomes while minimizing any potential adverse results. This thorough information will allow you to perceive Tren dosage for newbies and arm you with the data and understanding you have to confidently begin your cardiovascular health quest. We’ve obtained you coated on every little thing from determining the proper starting dose to minimizing risks.
This solely applies to smart use of HGH, although, including reasonable doses and not using HGH consistently over intervals of years – as that is the place very serious health impacts can come along. Depending on your specific objectives, these will typically be the most popular steroids, like testosterone and Trenbolone for bulking cycles and Anavar or Winstrol if you’re on a slicing cycle. For the most hardcore fat loss, Clenbuterol (which just isn’t a steroid) is usually stacked with HGH. Deca Durabolin and Anadrol are different steroids that males will stack with HGH. Throughout this complete guide, we’ve explored various features of Trenbolone, from its chemical construction and mechanism of action to its makes use of, unwanted side effects, and alternatives. The potency of Trenbolone is unquestionable – its capability to quickly increase muscle mass, energy, and total efficiency is unparalleled among anabolic steroids. Its distinctive properties, corresponding to its resistance to aromatization and its effects on nutrient partitioning, set it aside from many other compounds in its class.
Trenbolone can even cause long-term well being issues similar to liver toxicity, high levels of cholesterol, and high blood pressure. Liver toxicity is a specific concern, as trenbolone is metabolized by the liver and might cause damage over time. To handle the unwanted side effects of trenbolone, you will want to use the steroid responsibly and observe a proper cycle. Customers ought to begin with a low dose and gradually enhance it over time to attenuate the risk of adverse results. As a bodybuilder looking to maximize muscle progress with trenbolone, it is important to comply with a wholesome and balanced food regimen. A calorie surplus is necessary to assist muscle development, however it is equally essential to ensure that you’re consuming sufficient protein, wholesome fat, and carbohydrates to gasoline your workouts.
References:
https://www.generation-n.at/forums/users/pepperorder15/
Woh I like your posts, saved to fav! .
Girls who take it have reported an increase in Libido ranges, nonetheless, this can begin to put on off after a couple of weeks of utilization. When you’re employed out, you’re primarily causing microscopic tears in your muscle fibers. In order for your muscle tissue to restore this injury and grow stronger, they need adequate time to rest and recuperate. Sadly, the calls for of every day life can often make it difficult to get sufficient rest. Satellite Tv For Pc cells are important for muscle growth because they assist to restore and regenerate broken muscle fibers. See, all Steroids have good and unhealthy effects, and depending on who you might be, what your goals are, and so forth., certain Steroids might be good for you and others might not. I must also point out that if you would like to speed up weight loss you possibly can safely use Anvarol with (Clenbuterol) for even higher outcomes.
Also the cardiovascular strain from the altered cholesterol levels can lead to long run coronary heart well being problems. So though Anavar is good at preserving lean muscle mass, bettering protein synthesis and different benefits, the results it gives comes at a high cost. However do note that though Anavar is much less likely to cause virilization, it can still happen. The danger of this occurring increases when the steroid is utilized in excessive doses or slicing cycles of more than 8 weeks. Especially since stronger steroids have larger risk of virilization makes them too dangerous to make use of. I provides you with an easy to comply with guide on Anavar for girls – both when used for weight loss and also when used as a fat loss agent on cutting cycles.
Ostarine also possesses constructive metabolic effects, growing calorie expenditure and satiety. It is also illegal to use ostarine for cosmetic purposes, with only scientific analysis permitted. Nonetheless, as you’ll be purchasing from an unlicensed seller, you will not be obtaining pure Anavar. As it’s unlawful for non-prescription use, attempting to buy Anavar can prove powerful. There are some on-line sites which purport to promote this synthetic—but receiving one hundred pc pure Anavar just isn’t assured. As long as the dosage is kept round 10 mg per day, this is not going to lead to hulk-like proportions.
Still, we should remember that even a 4-week cycle of Anavar can produce results, which will keep prices down somewhat. Notice that this doesn’t essentially mean it’s authorized to import or promote AAS in such international locations – legal guidelines differ. Whereas personal possession may not trigger you authorized issues, you would end up in trouble if you’re caught trying to sell Anavar to somebody. Most folks would discover that the worth of pharmaceutical-grade Anavar would just not be price it, as it is significantly more expensive than most other, more broadly obtainable steroids. Very little Oxandrolone is produced for human medical use nowadays, so there’s hardly any supply of pharma-grade merchandise. That means it won’t be low-cost if you can find some (and make sure it’s reliable and genuine). Masteron is thought to be a greater mood enhancer than Anavar, but this effect could be very individual-dependent.
Is quite obvious that there’s nothing that may show how good a compound works by checking the pictures, nonetheless, is at all times a good thing to learn the reviews and testimonials. For non-competitive bodybuilders, we don’t see HGH being well price the danger, with it only producing delicate to moderate results. However, many steroids do require PCT as a result of vital injury to the HPTA axis. HGH doesn’t cause androgenic effects, as there is not a 5α-reductase conversion of testosterone into DHT.
As Quickly As you’ve completed an Anavar cycle and observed the outcomes, it’s time to reassess your targets and plan your subsequent steps. Summarizing this, proper Anavar dosage for girls bodybuilders lies between a spread of 5-20mg per day, with novices beginning on the lower finish of the spectrum. Consistency in dosage timing and respecting the body’s want for a breather before the next cycle are important points to notice to have the ability to undertake a responsible approach toward utilizing Anavar. Adherence to those suggestions encourages optimal health outcomes while minimizing health dangers. Over time and tolerance build-up, the dosage could be increased incrementally, however it is usually advised to not exceed 20mg per day, preserving security concerns paramount.
When a female takes Clenbuterol at high doses for prolonged durations, the danger of those life-changing side effects creating will enhance. This is a vital cause ladies should keep their Clenbuterol dosage as low as potential. We can nonetheless get an general thought of all the possible unwanted effects reported by those utilizing Clen for bodybuilding and competition functions. If you’re already an anabolic steroid consumer, you probably can expect Clen’s unwanted aspect effects to be very completely different from what you’re used to with steroids. Clen is a wholly completely different sort of compound, so it acts in a really totally different means than steroid hormones.
Any adjustments in levels of cholesterol shall be reversed once the cycle is finished. Stronger testosterone levels in ladies improve intercourse want, which is why black women have larger libidos than white women on average, despite producing extra testosterone than white ladies on average. It is preferable if the program includes weight reduction and light coaching; weight reduction will occur without them, however attaining beautiful shapes and toned pores and skin without sports is not going to be attainable. As you can see, the dosage of Anavar is set by the user’s expertise with steroids and the way they’re used.
(Personally, I’ll use the drug for at least 6–8 weeks.) Spreading out my dose all through the day on the same tempo every time (20 mg/20 mg/20 mg) yields the best results for me. Use 50 mg of clomid every day through the post-cycle therapy section, and you want to get well rapidly. The average period of an Anavar cycle for males is roughly eight weeks, whereas the utmost period for ladies is six weeks. Instead of using Anavar continuously for extended intervals of time, the most secure and most profitable way to forestall virilization is to take the drugs in cycles of some weeks and in low doses.
Thus, weighing your self to trace fat loss on Anavar is of little use, due to its simultaneous muscle-building properties. Nevertheless, Anavar for girls has a low danger of manufacturing virilization signs, if reasonable doses are used. The commonplace rule for Anavar is to have an equal amount of time each «on» and «off» the steroid. Moreover, it is essential to have proper post-cycle therapy or PCT to maintain up optimum health. This will allow enough time for the steroid to take effect and offer you an additional increase of vitality during your lifts. Anavar (Oxandrolone) is a game-changing steroid that may ship outstanding ends in just a matter of weeks.
Even should you merely use Anavar, you still require post-cycle therapy because, without it, your natural testosterone manufacturing operate is not going to be restored for many months. In the in the meantime, you will likely experience the disagreeable signs of low testosterone. Keep In Mind, everyone’s journey is unique, and it’s essential to take heed to your body and adjust your plan as wanted. By following the following tips, incorporating recommendation from experienced people, and staying committed to your objectives, you presumably can unlock the incredible results of Anavar before and after. Empower yourself, keep devoted, and embrace the transformative energy of Anavar on your health journey. At a dosage of 50–60 mg per day for 4 weeks, it is doubtful that Anavar will suppress your urge for food.
References:
steroid transformation before and after (https://2ubii.com/@carlohunter22?page=about)
Thus, taking this medicine might counteract the anabolic results of Anavar, causing bodybuilders to be unsatisfied with their outcomes. Anavar and all anabolic steroids are basically forms of exogenous testosterone; thus, Anavar will improve muscle mass. Some folks utilizing anabolic steroid medication have developed cysts or tumors of the liver or spleen. These conditions can occur with out warning or symptoms and can result in liver failure, inside bleeding, cancer, or death.
In summary, if you are utilizing Anavar and are topic to drug testing, it is very important concentrate on its detection time in different varieties of drug exams. Using drugs to move a drug test just isn’t really helpful and could be harmful. When it comes to utilizing Anavar, it could be very important be conscious of the dosage and cycle pointers to ensure that you are utilizing it safely and successfully.
Research published in Anabolics reveals that a day by day dose of 20mg has little effect on liver enzymes. In addition to well being concerns, shopping for Anavar via unofficial channels exposes users to legal penalties. Penalties may embrace fines, imprisonment, or both, depending on the jurisdiction. It is essential to know the laws and regulations within the country where one plans to purchase and use Anavar. Amongst these are the potential to buy counterfeit merchandise or mislabeled substances, which can result in extreme health issues. The high quality and purity of the product are often questionable in these scenarios. To decrease such dangers, it’s crucial to discover a trustworthy and dependable supply when looking for Anavar.
Clenbuterol works by stimulating thermogenesis, inflicting an increase in physique temperature, and elevating the metabolism. It also stimulates lipolysis by instantly concentrating on fats cells through the removal of triglycerides. Clenbuterol’s fat-burning effects may be attributed to its highly effective results on the central nervous system (CNS). Clenbuterol is a beta-2 sympathomimetic and is usually used in the therapy of hypotension. It can also be a bronchodilator, successfully opening the airways as a end result of leisure of easy tissue. Testosterone undecanoate is the exception to this rule, the place dietary fat improves absorption. I’m not sure if it’s related, but I’m 30, 1.79 m tall, and weigh sixty five kg.
It’s essential to observe these signs and seek medical recommendation promptly if they happen. Always remember, your well being comes first, and the pursuit of fitness targets ought to never compromise it. Whereas no steroid is totally side-effect-free, Anavar is taken into account one of the safest steroids when used correctly. ✔️ Boosts Phosphocreatine Levels in Muscle Cells – This will increase ATP manufacturing, supplying you with more energy, endurance, and sooner restoration between sets. Athletes must look after their liver, as the primary provide of glycogen is saved within the organ. When coaching intensely, blood sugar levels can turn into low, making such glycogen shops very helpful to efficiency.
Well, in this Anavar and Clen cycle information, I’ll take you thru a deep dive into each, exploring how they work together to assist you shed weight and construct lean muscle. Before starting a course of Anavar, it could be very important ensure there are no underlying medicalconditions that could be made worse by its use. Also, Anavar can influence a person’s blood sugar levels, so people with diabetes ought to solely take this drug underneath the supervision of their doctor. Moreover, Anavar is not suitable for pregnant ladies or those who are breastfeeding. Research have shown that this drug has brought on critical, generally deadly liver problems together with liver failure, liver cysts, and liver tumors in uncommon circumstances of heavy usage over extended periods of time. However, Anavar can also be identified to be onerous on the liver, and when mixed with alcohol, the risk of liver harm is considerably increased.
It helps to extend your strength, energy, and energy ranges while additionally helping to burn fats. Anvarol is made with a mix of natural components which have been confirmed to be just as effective as Anavar but without nasty unwanted facet effects. Anavar is also much less more doubtless to cause water retention, which might lead to bloating and other well being issues. Nevertheless, Testosterone is more practical at rising muscle mass and energy, especially when used in larger doses.
It’s when a steroid consumer goes to use something aside from the «kick-starting» steroid in their cycle as the main steroid or the spine of it. If you have issues with unwanted side effects that do not go away or they turn out to be worse, discuss with your doctor or pharmacist. They can talk about choices for managing side effects or different obtainable remedy choices.
Firstly, we discover that masculinization happens in girls when androgen ranges are high and estrogen ranges are low. Anadrol is androgenic but also estrogenic, stopping this ratio from turning into imbalanced. Nonetheless, people who genetically respond nicely to Anadrol can expertise increased well-being as a outcome of giant increase in testosterone. 17-alpha-methyl dihydrotestosterone is a potent androgen, which explains why androgenic unwanted effects are attainable regardless of it having a low androgenic rating.
Men produce testosterone of their testes, whereas women produce testosterone in their ovaries. Right Now, Anavar is in opposition to the law for leisure use in virtually each country on the planet, except Mexico, the place it might be bought at an area pharmacy. Some Anavar customers report large pumps, normally within the lower again, which could be uncomfortable or painful. This can usually feel like a locking, cramping sensation contained in the muscle that may last for several minutes or hours. Consequently, the individual might not be able to end their workout as a result of severe discomfort. This is as a result of of water filling contained in the muscle cell and fluid being expelled exterior the muscle cell. Consequently, as extracellular water is no longer obscuring superficial veins, they turn out to be more visible.
References:
how are the (https://gharbhoomi.com/profile/milliemonash32)
Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me.
Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me.